Expanding the accessible chemical space by solid phase synthesis of bicyclic homodetic peptides.
نویسندگان
چکیده
Norbornapeptides (bicyclo[2.2.1]heptapeptides) and related bicyclic homodetic peptides were prepared by solid-phase peptide synthesis using an orthogonal protection scheme. These conformationally rigid peptides cover an almost pristine area of peptide topological space and adopt globular shapes similar to those of short α-helical peptides.
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ورودعنوان ژورنال:
- Chemical communications
دوره 47 47 شماره
صفحات -
تاریخ انتشار 2011